Dietary fiber ameliorates sleep disturbance connected to the gut–brain axis

睡眠(系统调用) 肠道菌群 昼夜节律 肠-脑轴 免疫系统 内分泌系统 血清素 生物 睡眠障碍 内分泌学 内科学 医学 神经科学 免疫学 受体 激素 认知 操作系统 计算机科学
作者
Mengsheng Tang,Xiaoran Song,Weiwei Zhong,Yan Xie,Yanan Liu,Xin Zhang
出处
期刊:Food & Function [Royal Society of Chemistry]
卷期号:13 (23): 12011-12020 被引量:33
标识
DOI:10.1039/d2fo01178f
摘要

Circadian rhythms play an important role in maintaining normal physiological and psychological functions of the body, including regulating sleep patterns. External factors such as poor eating habits and work and rest patterns of modern people can disrupt the circadian rhythm, resulting in sleep disorders such as difficulty falling asleep and frequent waking up. The gut flora uses the "gut-brain axis" as a bridge to establish a connection with sleep, mainly including immune pathways, neural pathways, and endocrine pathways. Meanwhile, this article emphasizes that increasing the intake of dietary fiber in the daily dietary structure is beneficial for ameliorating sleep disorders. This is attributed to the metabolism of dietary fiber in the colon, increasing the type and quantity of probiotics and their representative metabolites, short-chain fatty acids (SCFAs), in the gut. They modulate sleep disorders by significantly improving the damaged gut barrier, stimulating the secretion of sleep cytokines, inhibiting inflammatory pathways, and increasing serotonin secretion. These provide new strategies for improving human sleep disorders from the perspective of the gut microbiota.
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