Case Report: Primary Pancreatic Lymphoma in a Hepatitis C Career: A Case Report of an Uncommon Extrahepatic Manifestation

Primary pancreatic lymphoma (PPL) is an exceptionally rare malignancy, often misdiagnosed as pancreatic adenocarcinoma due to overlapping and non-specific clinical and radiological features. Hepatitis C virus (HCV) infection has been increasingly associated with the development of lymphoproliferative disorders, particularly B-cell non-Hodgkin’s lymphoma (NHL). Herein, we present a case of a 63-year-old male with chronic HCV infection and F2 hepatic fibrosis who presented with abdominal pain, pruritus, and weight loss. Radiological imaging revealed a pancreatic mass which was subsequently confirmed via histopathological examination to be diffuse large B-cell lymphoma (DLBCL). Despite the initiation of antiviral therapy, the patient succumbed before starting chemotherapy. This case underscores the potential association between HCV infection and PPL, highlighting the importance of early antiviral treatment to prevent severe extrahepatic complications.