单线态氧
光动力疗法
活性氧
锰
化学
线粒体
光化学
氧气
生物物理学
生物
生物化学
有机化学
作者
Shuna Wang,Menghui Ma,Qingjing Liang,Xiaoyan Wu,Khurram Abbas,Junfa Zhu,Qian Xu,Antônio Cláudio Tedesco,Bo Hong
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2022-04-27
卷期号:5 (5): 6679-6690
被引量:17
标识
DOI:10.1021/acsanm.2c00716
摘要
The sustained rapid growth of tumor cells depends directly on the activity of mitochondria, which are important targets for many cancer drugs. Here, we report on a self-targeting method for mitochondria, a high atom efficiency nanoplatform, Mn/HA-CDs, made from hyaluronic acid-derived carbon dots (HA-CDs) and Mn2+ in a coordination structure of Mn-N5. We found that the Mn/HA-CDs with atomically dispersed Mn (0.73%) can generate reactive oxygen species (ROS) with a high atom economy. Particularly, its singlet oxygen (1O2) quantum yield (0.40) is 3 times higher than that of the previous HA-CDs (0.13). Active absorption of Mn/HA-CDs by mitochondria inhibits mitochondrial superoxide dismutase (SOD) enzyme function, intensifies ROS damage to the mitochondria, and eventually promotes the photodynamic therapy (PDT) effect on tumor cells. Our findings suggest that targeting mitochondria with single-atom metal-anchored CDs for a better PDT effect is a viable method of treating tumors.
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