再髓鞘化
神经炎症
小胶质细胞
生物
多发性硬化
中枢神经系统
神经科学
髓鞘
表型
免疫学
细胞生物学
髓样
炎症
生物化学
基因
作者
Dylan A. Galloway,Stephanie N. Blandford,T. H. Berry,John B. Williams,Mark Stefanelli,Michelle Ploughman,Craig S. Moore
出处
期刊:Glia
[Wiley]
日期:2018-12-11
卷期号:67 (5): 857-869
被引量:41
摘要
Abstract In the injured central nervous system, myeloid cells, including macrophages and microglia, are key contributors to both myelin injury and repair. This immense plasticity emphasizes the need to further understand the precise molecular mechanisms that contribute to the dynamic regulation of myeloid cell polarization and function. Herein, we demonstrate that miR‐223 is upregulated in multiple sclerosis (MS) patient monocytes and the alternatively‐activated and tissue‐regenerating M2‐polarized human macrophages and microglia. Using miR‐223 knock‐out mice , we observed that miR‐223 is dispensable for maximal pro‐inflammatory responses, but is required for efficient M2‐associated phenotype and function, including phagocytosis. Using the lysolecithin animal model, we further demonstrate that miR‐223 is required to efficiently clear myelin debris and promote remyelination. These results suggest miR‐223 constrains neuroinflammation while also promoting repair, a finding of important pathophysiological relevance to MS as well as other neurodegenerative diseases.
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