Lipophilicity: Chemical Nature and Biological Relevance

This chapter contains sections titled: Chemical Nature of Lipophilicity Chemical Concepts Required to Understand the Significance of Lipophilicity Molecular Charges and Dipoles Intermolecular Forces Solvation and Hydrophobic Effect Lipophilicity Systems Determination of Log P and Log D Traditional Factorization of Lipophilicity (Only Valid for Neutral Species) General Factorization of Lipophilicity (Valid For All Species) Biological Relevance of Lipophilicity Lipophilicity and Membrane Permeation Lipophilicity and Receptor Affinity Lipophilicity and the Control of Undesired Human Ether-a-go-go-related Gene (hERG) Activity Conclusions