顺铂
长非编码RNA
抗药性
医学
功能(生物学)
癌症
生物信息学
小RNA
计算生物学
药品
癌症研究
生物
药理学
核糖核酸
化疗
基因
遗传学
内科学
作者
Nadiah Abu,Kha Wai Hon,Shivapriya Jeyaraman,A. Rahman A. Jamal
出处
期刊:Future Oncology
[Future Medicine]
日期:2018-12-01
卷期号:14 (29): 3085-3095
被引量:24
标识
DOI:10.2217/fon-2018-0303
摘要
Since its discovery, cisplatin has become the key drug in chemotherapy for cancers. Nevertheless, chemoresistance in cancers has become an impediment in using cisplatin for cancer treatment. The resistance toward cisplatin is multifaceted as it involves multiple cellular pathways. Ever since the knowledge of long noncoding RNAs as modulators of various molecular pathways came to light, the interest in the biological function of lncRNAs as biomarkers has increased dramatically. Numerous studies have reported the link between the dysregulation of lncRNAs and drug resistance in cancers. More importantly, several lncRNAs were found to be vital in regulating cisplatin resistance. Therefore, this review summarizes the recent efforts in linking between cisplatin resistance and different types of lncRNAs.
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