Level of Brain Derived Neurotrophic Factor in pregnant Mice induced by Valproic Acid and Exercise in short time

Backgroud. About 50 percent woman had psychiatry symptom before pregnant. They had consumed drug for the rest life. The drug was valproic acid. Consumtion this drug during pregnancy would made neurodevelopmental disorder like Autism Spectrum Disorder (ASD). Brain Derived Neurothropic Factor (BDNF) have a role in development of Nervous system dams. The serum level increase during pregnancy and exercise Valproid acid which is consumed in pregnant may cause the decrease of BDNF level. Aims. Our study aims to investigate serum level of pregnant mice exposed to valproic acid and to investigate relationship level of BDNF with two condition exercise or not in short time. It is important to study to know, if BDNF level of mother is the better marker risk factor born child with ASD. Method. Pregnant mice differed into 4 group (control/1, control with exercise/ 2, valproid acid / 3, valproid acid with exercise /4). Valproic acid 500 mg/weight single dose was given at 16 days pregnant continue exercise for 4 days. Serum BDNF mother was examined. Result. Statistically, All groups had no significant value (p>0,05). But mean of both valproid acid groups, relatively decreased than control group. Exercise did not change the level.Conclusion. It could be concluded that consumtion of valproic acid could changed physiology of secretion of BDNF during prenatal, this is may be the causa of neurodevelopmental Disorder.