Biophysical modulation of peptide–membrane interactions

This chapter highlights current progress made in the elucidation of peptide–membrane interactions using model phospholipid membranes. The chapter covers specialist research findings published over the last few years to the time of its submission. It reviews literature sourced from different databases including Web of Science, RCSB Protein Data Bank and PubMed. A necessary reference to background information covers an unlimited timeframe. Naturally occuring and de novo peptide sequences with biologically relevant and membrane-mediated functions provide a primary focus of this discussion. Individual sections are arranged according to peptide–membrane models and measurement methods used for their characterisation, with a particular emphasis on spectroscopy measurements performed in solution. A number of mechanistic case studies are discussed in a separate section to give an overview of applied peptide–membrane systems.