Response surface analysis method was used to optimize microwave extraction of polysaccharide from Lycium barbarum.Results showed that the best extraction conditions were as follows:the highest yield(9.57%(w/w))of the polysaccharide was obtained under 300W of microwave power for 1.8min at solution-solid ratio of 26∶1(mL/g).The DPPH· clearance rate of the polysaccharide yielded under optimum conditions was 5% lower than BHA(0.1mg/mL concentration except),but the ORAC value and reducing power of the polysaccharide were slightly higher.On the whole,its antioxidizability was close to the polysaccharide yield by water extraction.