Abstract Directed interesterification reaction in solvents of cottonseed, peanut and cottonseed containing peanut, sesame and safflower oils was investigated with special reference to the influence of amount of sodium methoxide catalyst, oil content in solvent, temperature during the reaction and the nature of solvent on the characteristics of the reaction. The parameters were first studied with cottonseed oil and the conditions that favoured the reaction were adopted for peanut oil and cottonseed oil mixtures.