The regioselective synthesis of 2,5- and 4,5-disubstituted thiazoles via the cyclization of 2-oxo-2-(amino)ethanedithioates with isocyanides

Regioselective synthesis of 2-(methylthio)- N -aryl/alkylthiazole-5-carboxamides and ethyl-5-(aryl/alkylcarbamoyl)thiazole-4-carboxylates was carried out via the base-induced cyclization of methyl-2-oxo-2-(amino)ethanedithioates with TosMIC and ethyl isocyanoacetate.