硫代硫酸钠
顺铂
医学
耳毒性
肝母细胞瘤
听力损失
化疗
听力学
内科学
无机化学
化学
作者
Penelope Brock,Rudolf Maibach,Margaret Childs,Kaukab Rajput,Derek Roebuck,Michael Sullivan,Véronique Laithier,Milind Ronghe,Patrizia Dall’Igna,Eiso Hiyama,Bénédicte Brichard,Jane Skeen,María Elena Mateos,Michael Capra,Arun Rangaswami,Marc Ansari,Catherine Rechnitzer,Gareth J. Veal,Anna Covezzoli,Laurence Brugières
标识
DOI：10.1056/nejmoa1801109
摘要
The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk hepatoblastoma, without jeopardizing overall or event-free survival. (Funded by Cancer Research UK and others; SIOPEL 6 ClinicalTrials.gov number, NCT00652132 ; EudraCT number, 2007-002402-21 .).
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