µ-Acetylide and µ-alkenylidene ligands in “click” triazole syntheses

In a computational investigation, dinuclear and tetranuclear copper acetylide complexes display both superior stability and higher reactivity in the CuAAC reaction than do mononuclear complexes due to favored dicopper(I,III) µ-alkenylidene fragments, instead of ring strain in a CuCC intermediate.