麻疹病毒
生物
病毒
核糖核酸
病毒学
基因
小RNA
基因表达
转移RNA
麻疹
遗传学
接种疫苗
作者
Abhijeet Bakre,Catherine Duffy,Hani'ah Abdullah,Sara Louise Cosby,Ralph A. Tripp
标识
DOI:10.3389/fmicb.2021.671852
摘要
Respiratory syncytial virus (RSV) or measles virus (MeV) infection modifies host responses through small non-coding RNA (sncRNA) expression. We show that RSV or MeV infection of neuronal cells induces sncRNAs including various microRNAs and transfer RNA fragments (tRFs). We show that these tRFs originate from select tRNAs (GCC and CAC for glycine, CTT and AAC for Valine, and CCC and TTT for Lysine). Some of the tRNAs are rarely used by RSV or MeV as indicated by relative synonymous codon usage indices suggesting selective cleavage of the tRNAs occurs in infected neuronal cells. The data implies that differentially expressed sncRNAs may regulate host gene expression via multiple mechanisms in neuronal cells.
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