封锁
免疫检查点
抑制器
免疫系统
癌症研究
癌症
舱室(船)
髓源性抑制细胞
髓样
癌变
细胞
T细胞
医学
癌细胞
免疫学
生物
受体
内科学
遗传学
地质学
海洋学
作者
Liudmila L. Kodach,Maikel P. Peppelenbosch
标识
DOI:10.1053/j.gastro.2021.03.047
摘要
With interest we read the study by Kim et al,1 which appeared in the February issue of Gastroenterology. In this study, the authors exploit elegant mouse models to dissect the relative contribution of the myeloid-derived suppressor cells (MDSCs), the immune cell compartment and programmed cell death-1 (PD-1) receptor and its ligand PD-L1 to gastric carcinogenesis. Blockade of PD-1/PD-L1 is an effective strategy for counteracting cancer in a variety of clinical settings, but seems to be largely ineffective against gastric cancer.
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