生物医学
生物
基因组
内源性逆转录病毒
人类基因组
基因
遗传学
病毒学
进化生物学
计算生物学
作者
Yuhe Song,Xiang Li,Xiaoman Wei,Jie Cui
标识
DOI:10.1007/s12250-021-00387-7
摘要
Human endogenous retroviruses (HERVs) were formed via ancient integration of exogenous retroviruses into the human genome and are considered to be viral "fossils". The human genome is embedded with a considerable amount of HERVs, witnessing the long-term evolutionary history of the viruses and the host. Most HERVs have lost coding capability during selection but still function in terms of HERV-mediated regulation of host gene expression. In this review, we summarize the roles of HERV activation in response to viral infections and diseases, and emphasize the potential use of HERVs as biomedicine markers in the early diagnosis of diseases such as cancer, which provides a new perspective for the clinical application of HERVs.
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