A double-blinded randomized controlled pilot study evaluating the efficacy of small interfering RNA (siRNA) inhibiting secreted protein acidic and rich in cysteine (SPARC) microneedle patch versus siRNA inhibiting SPARC and interleukin 4-receptor alpha microneedle patch in reducing scar volume

In our previous randomized intra-individually controlled clinical trial on early post-surgical scars, we found that dissolvable microneedle patches embedded with small interfering RNA (siRNA) against secreted protein acidic and rich in cysteine (SPARC) (siSPARC) significantly reduced scar volume compared with silicone sheets. The current pilot study builds on our previous study and investigates whether dissolvable microneedle patches embedding siRNA against SPARC and interleukin-4 receptor alpha (IL4-RA) (siSPARC + siIL4-RA) (Dual-siRNA therapy) confers further clinical improvement in flattening scars, compared with microneedle patches embedding siSPARC alone (Mono-siRNA therapy).