转分化
再生(生物学)
细胞生物学
再生医学
祖细胞
细胞命运测定
生物
干细胞
细胞分化
转录因子
生物化学
基因
作者
Hua Qin,Andong Zhao,Xiaobing Fu
标识
DOI:10.1007/s11427-018-9349-5
摘要
Chemical modulation of cell fates has been widely used to promote tissue and organ regeneration. Small molecules can target the self-renewal, expansion, differentiation, and survival of endogenous stem cells for enhancing their regenerative power or induce dedifferentiation or transdifferentiation of mature cells into proliferative progenitors or specialized cell types needed for regeneration. Here, we discuss current progress and potential using small molecules to promote in vivo regenerative processes by regulating the cell fate. Current studies of small molecules in regeneration will provide insights into developing safe and efficient chemical approaches for in situ tissue repair and regeneration.
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