Copper-catalyzed three-component radical aminoazolation of vinylarenes with N-fluorobenzenesulfonimide and trimethylsilylazole derivatives

A copper-catalyzed three-component radical aminoazolation of vinylarenes with N-fluorobenzenesulfonimide (NFSI) and trimethylsilylazole derivatives has been developed. This methodology provides an efficient and straightforward approach to generate various β-sulfoamino azoles in good to excellent yields. The protocol features exclusive chemo- and regioselectivity, and excellent functional group tolerance under mild conditions.