肿瘤微环境
癌症研究
免疫系统
渗透(HVAC)
免疫疗法
癌症免疫疗法
CD8型
黑色素瘤
PI3K/AKT/mTOR通路
免疫检查点
癌细胞
T细胞
光热治疗
化学
医学
癌症
免疫学
材料科学
信号转导
纳米技术
内科学
复合材料
生物化学
作者
Quan Liu,Zhe Sun,Yanhong Duo,Yin Li,Kongpeng Lv,Ludan Yue,Qian‐Fang Meng,Daotai Nie,Jiaojuan Chen,Dixian Luo,Liping Liu,Lang Rao
出处
期刊:ACS materials letters
[American Chemical Society]
日期:2023-05-18
卷期号:5 (6): 1738-1751
标识
DOI:10.1021/acsmaterialslett.2c01136
摘要
Immune checkpoint blockade has been regarded as a highly promising cancer immunotherapy approach. However, inefficient immune cell infiltration and the immunosuppressive tumor microenvironment (TME) remain significant causes of low clinical response rates. Here, we identified that trivalent chromium irons (Cr3+) could enhance tumor infiltration of immune cells including M1-type tumor-associated macrophages and CD8+ T cells. Mechanistically, this effect is dependent on the expression of macrophage inflammatory protein-1α (MIP-1α) and the PI3K/Akt/mTOR pathway. Moreover, the Cr-based nanoparticles (Cr NPs) exhibited superior photothermal properties under near-infrared laser irradiation, showing great potential in transforming “cold” tumors into “hot” ones. In combination with the PD-1/PD-L1 pathway inhibitor, we demonstrated that the Cr NPs significantly improved anticancer efficacy in mouse models of hepatoma and melanoma by increasing antitumor immune cell infiltration and relieving immunosuppressive TME. Overall, the Cr NPs offer a new dual-functional platform for local and systemic cancer treatments, paving the way toward cancer photometalloimmunotherapy.
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