Spontaneous Remission and Subsequent Relapse in Pediatric Acute Myeloid Leukemia ( AML ‐ M5 ): A Case Report and Literature Review

ABSTRACT Spontaneous remission (SR) in pediatric acute myeloid leukemia (AML‐M5) is extremely rare and is typically characterized by short duration and high relapse risk. We report a case of AML‐M5 in a child at Yunnan Children's Medical Center who achieved SR following blood transfusions and anti‐infective therapy, without leukemia‐specific treatment, but relapsed one month later. A comprehensive literature review was also conducted to explore factors contributing to SR in pediatric leukemia, with the aim of informing treatment protocols and improving outcomes for AML patients.