[Expert consensus on rational clinical application of amphotericin B deoxycholate (2022)].

Amphotericin B (AmB) is an antifungal drug with the broadest spectrum and the most robust antifungal activity in clinical practice. Although there are many kinds of lipid formulations which significantly reduce the toxicity and side effects of amphotericin B deoxycholate (AmBd), AmBd will still play an important clinical role in China for a long time since lipid formulations are substantially more expensive. To standardize the clinical application of AmBd, well-known experts in this field were invited to reach a consensus on the antifungal properties, pharmacokinetic characteristics, dosage regimen, clinical application, prevention and treatment of adverse reactions of AmBd.两性霉素B（AmB）是目前临床上抗真菌谱最广，活性最强的抗真菌药物，尽管有多种脂质制剂上市，极大地降低了两性霉素B脱氧胆酸盐（AmBd）的不良反应，但价格昂贵。因此，在我国AmBd在未来很长的一段时间内仍有重要的临床地位。为了提高AmBd临床疗效，降低毒副反应，编写组邀请国内该领域知名专家就AmBd的抗菌特性、药动学特点、给药方案、临床应用、不良反应防治等方面达成了共识，规范AmBd的临床应用。.