薯蓣皂甙元
肠道菌群
内分泌学
药理学
神经炎症
肠-脑轴
丁酸盐
小胶质细胞
皂甙元
化学
医学
内科学
炎症
血压
免疫学
生物化学
病理
有机化学
替代医学
发酵
作者
Mengying Xu,Bo Peng,Juan Bai,Lü Li,Yan Du,Zhiqiang Wang,Shasha Li,Xiaoxi Liu,Yunyun Dong,Jun Wu,Ling-Xiao Xiong,Lei Chen,Hong-Bao Li,Hongli Jiang
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:13 (18): 9532-9543
被引量:2
摘要
Gut microbiota is well-established to regulate host blood pressure. Diosgenin is a natural steroid sapogenin with documented anti-inflammatory, antioxidant and antihypertensive properties. We aimed to investigate whether the antihypertensive effects of diosgenin are mediated by the microbiota-gut-brain axis in spontaneously hypertensive rats (SHR). 15-Week-old male Wistar Kyoto rats (WKY) and age-matched SHR were randomly distributed into three groups: WKY, SHR treated with a vehicle, and SHR treated with diosgenin (100 mg kg-1). Our results showed that diosgenin prevented elevated systolic blood pressure (SBP) and ameliorated cardiac hypertrophy in SHR. Moreover, the gut microbiota composition and intestinal integrity were improved. Furthermore, increased butyrate-producing bacteria and plasma butyrate and decreased plasma lipopolysaccharides were observed in SHR treated with diosgenin. These findings were associated with reduced microglial activation and neuroinflammation in the paraventricular nucleus. Our findings suggest that diosgenin attenuates hypertension by reshaping the gut microbiota and improving the gut-brain axis.
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