毒力
生物
微生物学
细菌
基因
毒力因子
脂多糖
细菌外膜
病毒学
免疫学
大肠杆菌
遗传学
作者
Bai Wei,Hyesuk Seo,Ke Shang,Junfeng Zhang,Jong-Yeol Park,Yea-Jin Lee,Yuri Choi,Sang-Won Kim,Se-Yeoun Cha,Hyung‐Kwan Jang,Min Kang
出处
期刊:한국가금학회지
[The Korean Society of Poultry Science]
日期:2021-12-01
卷期号:48 (4): 327-335
标识
DOI:10.5536/kjps.2021.48.4.327
摘要
Riemerella anatipestifer (RA) can cause septicemia, polyserositis, and ataxia in ducks. It can also colonize the upper respiratory tract of healthy ducks. These differences in pathogenicity are probably the result of diverse mechanisms of virulence in different strains. Since serum resistance is a feature frequently found in systemic pathogens, 130 RA strains having different clinical origins were tested. A variety of serum susceptibility levels were detected. Pharynx strains from healthy ducks were mainly susceptible to the bactericidal effect of the serum, while systemic strains were serum resistant. Heat-treatment of the sera abolished the bactericidal activity, indicating that complement is a key factor in this effect. In an attempt to associate serum-resistance to surface determinant genes of the bacteria, we screened for six genes involved in lipopolysaccharide synthesis and membrane proteins in RA. Of these, three genes (AS87_09335, AS87_00480, and AS87_05195) encoding outer membrane proteins might be implicated in serum resistance statistically. The results indicate that serum resistance is a virulence mechanism in RA.
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