Recent advance in inherited arrhythmogenic disease-associated ion channelopathies

Sudden cardiac death of young people is mainly caused by arrhythmia with genetic defects,which is called inherited arrhythmogenic diseases(IADs).The most common kinds of IADs are long QT syndrome(LQTS),short QT syndrome(SQTS),Brugada syndrome(BrS) and catecholaminergic polymorphic ventricular tachycardia(CPVT).Abnormal cardiac-electrical activities caused by the mutation of the subunit genes coding the ion channels in myocardial cells are the major cause of IADs.In this review,we focus on the advances in pathophysiological and genetic research of the channelopathies mentioned above.