试剂
化学
范围(计算机科学)
组合化学
有机合成
戒指(化学)
理论(学习稳定性)
水解
功能群
反应条件
计算化学
有机化学
计算机科学
催化作用
程序设计语言
聚合物
机器学习
作者
Pavel S. Nosik,Mykola O. Pashko,Andrii S. Poturai,Denys A. Kvasha,Alexander Pashenko,А. Б. Роженко,S. Yu. Suikov,Dmitriy M. Volochnyuk,Sergey V. Ryabukhin,Yurii L. Yagupolskii
标识
DOI:10.1002/ejoc.202100921
摘要
Abstract A general approach to gem ‐difluorocyclopropenes synthesis based on the reaction of alkynes with Ruppert‐Prakash reagent is reported. The proposed method is evaluated for the synthesis of a wide difluorocyclopropenes scope based on their bench lifespan and hydrolytic stability. The tolerance of the method for common functional groups was shown. Previously unavailable difluorocyclopropenes substituted with aliphatic were prepared using the proposed procedure. The retain of stability was proven by the multigram scale synthesis and further storage in the temperature interval −78 to −4 °C over a year. This makes them attractive building blocks and intermediates for organic synthesis. The reasons for dropping stability were defined. The relations between the structure of the substituents and the stability of the difluorocyclopropene ring were determined and discussed.
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