纳米探针
荧光
近红外光谱
结直肠癌
高分辨率
材料科学
医学
纳米技术
纳米颗粒
癌症
光学
遥感
物理
内科学
地质学
作者
Ge Xu,Qinglong Yan,Xiaoguang Lv,Ying Zhu,Kai Xin,Bowen Shi,Rongchen Wang,Jian Chen,Wei Gao,Ping Shi,Chunhai Fan,Chunchang Zhao,He Tian
标识
DOI:10.1002/anie.201712528
摘要
Fluorescent probes in the second near-infrared window (NIR-II) allow high-resolution bioimaging with deep-tissue penetration. However, existing NIR-II materials often have poor signal-to-background ratios because of the lack of target specificity. Herein, an activatable NIR-II nanoprobe for visualizing colorectal cancers was devised. This designed probe displays H2 S-activated ratiometric fluorescence and light-up NIR-II emission at 900-1300 nm. By using this activatable and target specific probe for deep-tissue imaging of H2 S-rich colon cancer cells, accurate identification of colorectal tumors in animal models were performed. It is anticipated that the development of activatable NIR-II probes will find widespread applications in biological and clinical systems.
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