活性氧
化学
抗菌活性
组合化学
葡萄糖酸
催化作用
葡萄糖氧化酶
沸石咪唑盐骨架
纳米技术
材料科学
生物化学
有机化学
细菌
金属有机骨架
生物传感器
生物
吸附
遗传学
作者
Muxue Wang,Xi Zhou,Yunhong Li,Yuanlin Dong,Jiashen Meng,Shuai Zhang,Linbo Xia,Zhaozhi He,Lei Ren,Zhiwei Chen,Xingcai Zhang
标识
DOI:10.1016/j.bioactmat.2022.01.036
摘要
The abuse of antibiotics makes bacterial infection an increasingly serious global health threat. Reactive oxygen species (ROS) are the ideal alternative antibacterial approach for quick and effective sterilization. Although various antibacterial strategies based on ROS have been developed, many of them are still limited by insufficient antibacterial efficiency. Here, we have developed an acid-enhanced dual-modal antibacterial strategy based on zeolitic imidazolate frameworks-8 (ZIF8) -derived nanozyme. ZIF8, which can release Zn2+, is chosen as the carrier to integrate glucose oxidase (GOx) and gold nanoparticles (Au NPs) which can produce ROS via a cascade catalytic reaction. Thus, the bactericidal capability of ROS and Zn2+ have been integrated. More importantly, gluconic acid, a "by-product" of the catalytic reaction, can generate an acidic environment to promote both the ROS-producing and Zn2+-releasing, enhancing the overall antibacterial performance further. This triple-synergistic strategy exhibits extraordinary bactericidal ability at a low dosage of 4 μg/mL (for S. aureus) and 8 μg/mL (for E. coli), which shows a great potential of MOF-derived nanozyme for efficient bacterial eradication and diverse biomedical applications.
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