Objective To observe the therapeutic effect of Jiqikaibi capsule on rheumatoid arthritis and to investigate its mechanism. Methods 76 patients with rheumatoid arthritis were randomly divided into two groups, 46 patients in treatment group were treated with Jiqikaibi capsule, three piles once, three times a day;30 patients in control group were treated with Zhengqingfengtongning, two tablets once, twice a day, with a treatment course of one month for both groups. The therapeutic effects, improvement of symptoms and biochemical indexes before and after treatment were observed. Results The total effective rate was 76.1% in treatment group and 70% in control group. Conclusion Jiqikaibi capsule is effective in treating rheumatoid arthritis by improving the symptoms of patients, increasing the immunological function and improving the blood viscosity.