医学
湿疹面积及严重程度指数
皮肤科生活质量指数
特应性皮炎
杜皮鲁玛
内科学
生活质量(医疗保健)
皮肤病科
不利影响
回顾性队列研究
疾病
护理部
作者
Cataldo Patruno,Luca Potestio,Massimiliano Scalvenzi,Teresa Battista,Flavia Raia,Vincenzo Picone,Gabriella Fabbrocini,Maddalena Napolitano
标识
DOI:10.1080/09546634.2022.2102121
摘要
Special populations (SPs) involve people who require additional consideration in clinical research. Effectiveness of treatment or occurrence of side effects may be different in SPs with respect to not-SPs.To retrospectively compare the effectiveness and safety of dupilumab in AD treatment of SPs versus not-SPs.A 52-weeks retrospective study was performed enrolling patients with a diagnosis of moderate-to-severe AD undergoing treatment with dupilumab at labeled dosage. Patients were divided in Group A (SPs patients) and Group B (not-SPs patients). Disease severity was assessed using Eczema Area Severity Index (EASI), Pruritus-Numerical Rating Scale (P-NRS), and Dermatology Life Quality Index (DLQI) score at baseline and after 4 weeks (W4), W16, W24, and W52.A total of 263 patients were enrolled and divided in Group A (25) and Group B (238). SPs included history of cancer, severe kidney failure, viral hepatitis, neurological diseases, acquired immunodeficiency syndrome, and transplanted patients. A statistically significant reduction of EASI, DLQI, and P-NRS was assessed in both groups at each follow-up visit (p < .0001), without significant differences between the groups. No differences were recorded for safety.There are not significant differences between SPs and not-SPs as regards effectiveness and safety of dupilumab in AD management.
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