Biomarker‐Gated Photocatalysis Uncaging in Live System

, respectively. This "lock-and-key" mechanism enables two primary functionalities: enhanced bioimaging through signal amplification by biomarker-activated BODIPY catalysts, and an "AND-gate" therapeutic activation requiring both NTR presence and light exposure for the release of caged therapeutic agents like RNase A or doxorubicin. Our platform integrates bioresponsive chemistry with light-mediated control, offering a blueprint for logical gate-regulated cellular processes and advancing precision medicine with potential for more targeted and efficient therapies.