列线图
医学
内科学
前瞻性队列研究
比例危险模型
队列
多元分析
癌症
阶段(地层学)
多元统计
淋巴细胞
肿瘤科
胃肠病学
统计
生物
古生物学
数学
作者
Na Wang,Yulan Lin,Fa Chen,Fengqiong Liu,Jing Wang,Bingju Gao,Yu Qiu,Lisong Lin,Bin Shi,Baochang He
出处
期刊:Head & neck
[Wiley]
日期:2023-03-07
卷期号:45 (5): 1172-1183
摘要
To assess the prognostic role of gamma-glutamyl transpeptidase to lymphocyte count ratio (GLR) and develop a prognostic nomogram for patients with oral cancer.A prospective cohort (n = 1011) was conducted during July 2002 to March 2021 in Southeastern China.The median follow-up time was 3.5 years. Multivariate Cox regression (OS: HR = 1.51, 95% CI: 1.04, 2.18) and Fine-Gray model (DSS: HR = 1.68, 95% CI: 1.14, 2.49) both showed that high GLR could act as an indicator of poor prognosis. A nonlinear dose-response relationship was observed between continuous GLR and the risk of all-cause mortality (p for overall = 0.028, p for nonlinear = 0.048). Compare with TNM stage, time-dependent ROC curve proved that GLR-based nomogram model performs better in predicting prognosis (the area under curve for 1-, 3-, and 5-years mortality: 0.63, 0.65, and 0.64 vs. 0.76, 0.77, and 0.78, p < 0.001).GLR might be a useful tool in predicting prognosis for patients with oral cancer.
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