Pharmacokinetic and Biopharmaceutical Considerations in Prodrug Discovery and Development

This chapter contains sections titled: Introduction Understanding Pharmacokinetic/Pharmacodynamic Relationships Pharmacokinetics Tools for the Prodrug Scientist Enzymes Involved with Prodrug Conversion Use of the Caco-2 System for Permeability and Active Transport Evaluation XP13512: Improving PK Performance by Targeting Active Transport Prodrug Absorption: Transport/Metabolic Conversion Interplay Preabsorptive Degradation Biopharmaceutical-Based PK Modeling for Prodrug Design Conclusions References