We are pleased to serve as the Guest Editors of this Special Issue on IEEE Photonics Conference 2020 (IPC2020), published by the IEEE Photonics Technology Letters journal. The IEEE Photonics Conference (IPC) is the flagship conference of the IEEE Photonics Society and serves as a prominent meeting for the members and the broad photonics community. IPC2020 took place from September 28 to October 1, 2020. The technical program encompasses areas from biophotonics, nanophotonics, silicon photonics, microwave photonics, quantum photonics, photonics material, photonics devices, linear and nonlinear photonics, optical communications, and optical interconnects.