Prussian Blue and Its Analogues: From Properties to Biological Applications

Abstract The utilization of metal organic framework (MOF) nanocomposites in various biomedical applications has been widely studied because of their unique properties. In recently years, Prussian blue (PB) is widely used in clinical studied due to its biosafety, which has already been approved by USA Food and Drug Administration (FDA). Therefore, it is great urgent to systematically summarize the resent progress to better serve the broad community of researchers. This review focuses on the properties of PB and PB analogues (PBA), and their applications in biological field. A systemic introduction of the properties is presented, including abilities of photothermal, scavenging of reactive oxygen species and adsorption. A variety of biomedical applications, such as tumor therapy, anti‐bacterial infection, biosensor, bioimaging, excretion, ischemic stroke treatment, etc. have been discussed as well. Furthermore, the challenges, key factors, and the prospects in the clinical transformation of PB or PBA are simultaneously discussed. This review will provide reference and guidance for the design and application of PB and PBA in the future.