拉曼散射
基质(水族馆)
材料科学
拉曼光谱
纳米颗粒
银纳米粒子
纳米技术
碳化
碳纤维
光学
扫描电子显微镜
海洋学
物理
复合材料
地质学
复合数
作者
Kui Lai,Tao Xu,Qinli Ye,Ping Xu,Jianping Xie,Dongsheng Yan,Shanshan Zhu,Tao Jiang,Wei Xiong,Chenjie Gu
标识
DOI:10.1016/j.saa.2023.122971
摘要
Surface enhanced Raman scattering (SERS) is a rapid and non-destructive spectral detection technique, and has been widely implemented on trace-level molecule detection. In this work, a hybrid SERS substrate constructed by porous carbon film and silver nanoparticles (PCs/Ag NPs) was developed and then used for imatinib (IMT) detection in bio-environment. The PCs/Ag NPs was prepared by direct carbonizing the gelatin-AgNO3 film in the air atmosphere, and an enhancement factor (EF) of 106 was achieved with R6G as the Raman reporter. Hereafter, this SERS substrate was used as the label-free sensing platform to detect the IMT in the serum, and the experimental results indicate that the substrate is conducive to eliminating the interference from the complex biological molecules in the serum, and the characteristic Raman peaks belonging to IMT (10-4 M) are accurately resolved. Furthermore, the SERS substrate was used to trace the IMT in the whole blood, the trace of ultra-low concertation of IMT is rapidly discovered without any pretreatment. Thus, this work finally suggests that the proposed sensing platform provides a rapid and reliable method for IMT detection in the bio-environment and offers a potential for its application in therapeutic drug monitoring.
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