Molecular mechanisms involved in the destabilization of two types of R3–R4 tau fibrils associated with chronic traumatic encephalopathy by Fisetin

Chronic traumatic encephalopathy is a neurodegenerative tauopathy pathologically characterized by fibrillary tau aggregates in the depth of sulci. Clearing fibrous tau aggregates is considered a promising strategy in the treatment of CTE. Fisetin (FS), a natural polyphenolic small molecule, was confirmed to disassociate the tau filaments