Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions.

Purpose of reviewGabapentin and pregabalin bind to the alpha-2-delta calcium channel subunit and represent a novel analgesic drug class. The evidence base supporting their use for chronic neuropathic and early postsurgical pain is reviewed.Recent findingsMultiple, large, high-quality trials have dem