硅
化学
化学空间
碳纤维
纳米技术
硅烷化
药物发现
替代(逻辑)
组合化学
计算机科学
材料科学
有机化学
催化作用
生物化学
复合数
程序设计语言
算法
作者
Shinya Fujii,Yuichi Hashimoto
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2017-03-31
卷期号:9 (5): 485-505
被引量:75
标识
DOI:10.4155/fmc-2016-0193
摘要
Application of silyl functionalities is one of the most promising strategies among various ‘elements chemistry’ approaches for the development of novel and distinctive drug candidates. Replacement of one or more carbon atoms of various biologically active compounds with silicon (so-called sila-substitution) has been intensively studied for decades, and is often effective for alteration of activity profile and improvement of metabolic profile. In addition to simple C/Si exchange, several novel approaches for utilizing silicon in medicinal chemistry have been suggested in recent years, focusing on the intrinsic differences between silicon and carbon. Sila-substitution offers great potential for enlarging the chemical space of medicinal chemistry, and provides many options for structural development of drug candidates.
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