自噬
神经科学
神经退行性变
星形胶质细胞
中枢神经系统
生物
作者
Zhuchen Zhou,Jing Zhou,Jie Liao,Zhong Chen,Yanrong Zheng
标识
DOI:10.1007/s11064-022-03714-w
摘要
Astrocytes act as “housekeeping cells” for maintaining cerebral homeostasis and play an important role in many disorders. Recent studies further highlight the contribution of autophagy to astrocytic functions, including astrogenesis, the astrocytic removal of neurotoxins or stressors, and astrocytic polarization. More importantly, genetic and pharmacological approaches have provided evidence that outlines the contributions of astrocytic autophagy to several brain disorders, including neurodegeneration, cerebral ischemia, and depression. In this study, we summarize the emerging role of autophagy in regulating astrocytic functions and discuss the contributions of astrocytic autophagy to different CNS disorders.
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