转座因子
生物
基因组
遗传学
流动遗传元素
睡美人转座系统
Tn3转座子
换位(逻辑)
转座酶
基因
语言学
哲学
出处
期刊:ASM Press eBooks
[ASM Press]
日期:2015-05-26
卷期号:: 873-890
被引量:6
标识
DOI:10.1128/9781555819217.ch39
摘要
The piggyBac transposon superfamily is a relatively recently recognized transposon superfamily. The original piggyBac transposon was isolated from the genome of the cabbage looper moth, Trichoplusia ni in the 1980s. However, the second member of thepiggyBac-like element superfamily was not identified until 2000. It was not described as a transposon superfamily in the previous edition of Mobile DNA. In the last decade or so, a number of sequenced genomes have revealed that piggyBac-like elements are actually widespread DNA transposons. Active copies of the transposon have also been identified from another moth species, from frogs, and for the first time, from a mammal. Moreover, because the piggyBac transposon has a broad host spectrum from yeast to mammals, this mobile element has been widely used for a variety of applications in a diverse range of organisms. In this chapter, we will describe the discovery and diversity of the piggyBac transposon, its mechanism of transposition, and its application as a genetic tool. We will also provide two examples of genetic screening that the piggyBac transposon has enabled.
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