环丙烷化
卡宾
催化作用
产量(工程)
立体选择性
化学
有机化学
组合化学
材料科学
冶金
作者
Yongquan Ning,Mengtian Huo,Leying Wu,Xihe Bi
摘要
Here, a novel method for the stereoselective synthesis of alkynyl cyclopropanes, by the silver-catalyzed alkynylcyclopropanation of alkenes using alkynyl N-nosylhydrazones as alkynyl carbene precursors, is reported. This method provides a straightforward and powerful approach for preparing various alkynyl cyclopropanes in high yield with excellent stereoselectivities. In addition, the practicality of this method was demonstrated by gram-scale synthesis and late-stage modification of bioactive molecules.
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