海绵
分离(微生物学)
生物
属
计算生物学
萜类
生物活性
药物发现
化学
生态学
生物化学
植物
生物信息学
体外
作者
Qihao Wu,Bastien Nay,Min Yang,Yeke Ni,Hong Wang,Li‐Gong Yao,Xu‐Wen Li
标识
DOI:10.1016/j.apsb.2018.10.003
摘要
Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.
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