纳米探针
纳米技术
生物传感器
小RNA
纳米传感器
计算机科学
计算生物学
材料科学
生物
基因
纳米颗粒
遗传学
作者
Fan Yang,Huiting Lu,Xiangdan Meng,Haifeng Dong,Xueji Zhang
出处
期刊:Small
[Wiley]
日期:2021-12-02
卷期号:18 (10)
被引量:9
标识
DOI:10.1002/smll.202106281
摘要
DNA-based nanoprobes integrated with various imaging signals have been employed for fabricating versatile biosensor platforms for the study of intracellular biological process and biomarker detection. The nanoprobes developments also provide opportunities for endogenous microRNA (miRNA) in situ analysis. In this review, the authors are primarily interested in various DNA-based nanoprobes for miRNA biosensors and declare strategies to reveal how to customize the desired nanoplatforms. Initially, various delivery vehicles for nanoprobe architectures transmembrane transport are delineated, and their biosecurity and ability for resisting the complex cellular environment are evaluated. Then, the novel strategies for designing DNA sequences as target miRNA specific recognition and signal amplification modules for miRNA detection are presented. Afterward, recent advances in imaging technologies to accurately respond and produce significant signal output are summarized. Finally, the challenges and future directions in the field are discussed.
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