生殖系
生物
表观基因组
索马
表观遗传学
体细胞
跨代表观遗传学
后生
遗传(遗传算法)
进化生物学
遗传学
基因
DNA甲基化
神经科学
基因表达
作者
Colin C. Conine,Oliver J. Rando
标识
DOI:10.1038/s41576-021-00412-1
摘要
More than a century ago, August Weissman defined a distinction between the germline (responsible for propagating heritable information from generation to generation) and the perishable soma. A central motivation for this distinction was to argue against the inheritance of acquired characters, as the germline was partly defined by its protection from external conditions. However, recent decades have seen an explosion of studies documenting the intergenerational and transgenerational effects of environmental conditions, forcing a re-evaluation of how external signals are sensed by, or communicated to, the germline epigenome. Here, motivated by the centrality of small RNAs in paradigms of epigenetic inheritance, we review across species the myriad examples of intercellular RNA trafficking from nurse cells or somatic tissues to developing gametes.
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