Solvent Effect on Extraction Efficiency of Chlorogenic Acid from the Leaves of Eucommia Ulmodies by Ultrasonically Assisted Extraction Technique

Solvent effect on ultrasonically assisted extraction of chlorogenic acid from the leaves of Eucommia ulmodies was investigated.Extraction was carried out by using water,methanol,ethyl alcohol,ethyl acetate and acetone as solvent,respectively.The influence of the ratios and pH values of mixed solvent on the extraction efficiency of chlorogenic acid was evaluated.Results indicated that the extraction efficiency obtained using methanol as solvent was the highest and the optimized solvent for the ultrasonically assisted extraction of chlorogenic acid was 70% methanol water solution with a pH value of 4.5.