Design of an antioxidant nanogel for corneal alkali burn treatment

as a model of oxidative stress. Such nanogel treatment also suppressed the expression of inflammatory mediators including IL-1β, TNF-α, and IL-6 in macrophages that had been stimulated with LPS. Strikingly, in a rat alkali burn model, this nanogel was also able to satisfactorily suppress inflammation and control oxidative stress while inhibiting angiogenesis. Together, these results emphasize the promise of this novel nanogel as a tool to facilitate corneal injury repair, providing a novel therapeutic approach to the management of corneal alkali burns in the clinic.