Association Between C-Reactive Protein-Triglyceride-Glucose Index and Outcomes After Endovascular Thrombectomy in Patients with Acute Ischemic Stroke

OBJECTIVE: This study aimed to examine the relationship between the C-reactive protein-triglyceride-glucose index (CTI) and clinical outcomes in patients with acute stroke caused by large vessel occlusion in the anterior circulation following endovascular thrombectomy (EVT). METHODS: This retrospective study included patients who underwent EVT between January 1, 2020, and December 31, 2023. The CTI was computed using the following formula: 0.412 × Ln (C-reactive protein [mg/L]) + Ln (triglyceride [mg/dL] × fasting plasma glucose [mg/dL])/2. Based on the optimal cutoff value determined through receiver operating characteristic curve analysis, patients were categorized into low-CTI and high-CTI groups. The primary functional outcome was a favorable functional status at 90 days, defined as a modified Rankin Scale of 0-2. The relationship between CTI and clinical outcomes after EVT was assessed using univariate and multivariate logistic regression analyses. RESULTS: Data from 366 patients with acute stroke were analyzed. The univariate analysis revealed that higher CTI levels were associated with unfavorable functional outcomes. The multivariate-adjusted model demonstrated a significant association between CTI levels and clinical functional outcomes (95% confidence interval: 0.29-0.78; P = 0.004). The receiver operating characteristic curve analysis confirmed the ability of CTI to predict poor functional outcomes, with an area under the curve of 0.60. CONCLUSIONS: CTI shows a significant relationship with clinical functional outcomes in patients with acute anterior circulation large vessel occlusion ischemic stroke following EVT.