Histogenesis and control of the lung

The lung histogenesis,correlation genes and factors regulating or influencing development of fetal lung are summarized.The lung development begins with the outgrowth of paired lung buds from the foregut endoderm that invade the surrounding mesodermal mesenchyme in a genetically predetermined pattern of branching morphogenesis and lung specific cell differentiation. The endoblast epithelium interact with its around mesenchyme so that ensure lung normal morphogenesis.The lung development depends on whether the related genes or factors have been expressed normally.The expression of the development gene would affect that of downstream many other gene in order.At the same time,changing ambience factor of fetal lung may affect the expression of the mutuality genes so that it influences the development of fetal lung.