化学
亲核细胞
氮气
联轴节(管道)
计算化学
药物化学
有机化学
催化作用
工程类
机械工程
作者
Zi‐Liang Tang,Xuan‐Hui Ouyang,Ren‐Jie Song,Jin‐Heng Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-01-21
卷期号:23 (3): 1000-1004
被引量:26
标识
DOI:10.1021/acs.orglett.0c04203
摘要
We have disclosed a new radical-mediated decarboxylative C(sp3)-N cross-coupling of diacyl peroxides with nitrogen nucleophiles. The primary and secondary alkyl radicals derived from corresponding diacyl peroxides were generated by copper catalysis or by merging copper catalysis and photoredox catalysis, respectively. Various N-alkyl nitrogen nucleophiles, including indazoles, triazoles, indoles, purine, carbazole, anilines, and sulfonamide, were provided with a broad substrate scope and good functional group tolerance.
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